This thesis is the result of a 4-year collaboration between the Technical University of Munich and the BMW Group. The goal was to apply substructuring methods to the Noise Vibration Harshness (NVH) engineering needed for integrating electric climate compressors in upcoming vehicles. Specifically, the aim was to simulate the compressor noise in the cabin for different, virtual design variants of the isolation concept. Therefore, the methods from two broader fields were applied: First, the excitation of the compressor was modeled with component transfer path analysis (TPA) methods. Second, the full transfer path from the compressor to the driver’s ear is assembled from multiple subcomponent models, via dynamic substructuring (DS).